白塊線上課程

Week 1. Fundamental properties of neurons

Unit 1-1.Nerve cells and neural circuitry

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1-1Quiz

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Unit 1-2 .Cell biology of neurons

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1-2Quiz

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Unit 1-3.Structure and function of glial cells

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1-3Quiz

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Unit 1-4 . Membrane potential of the neuron

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1-4Quiz

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Unit 1-5.Equivalent circuit of the membrane potential

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1-5Quiz

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Unit 1-6.Electrotonic potential of the neuron

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1-6Quiz

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Unit 1-7.Diverse types of ion channels

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1-7Quiz

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Unit 1-8.Molecular basis of ion channels

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1-8Quiz

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Unit 1-9. Structure biology of ion channels

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1-9Quiz

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Week 2. Transmission of neural signals

Unit 2-1. Ionic basis of action potential

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2-1Quiz

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Unit 2-2. Conductance change during action potential

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2-2Quiz

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Unit 2-3. Gating mechanism of voltage-gated ion channels

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2-3Quiz

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Unit 2-4. Diverse voltage-gated ion channels determine action potential patterns

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2-4Quiz

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Unit 2-5. Propagation of action potential

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2-5Quiz

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Unit 2-6. Neural signal transmission across electrical synapses

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2-6Quiz

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Unit 2-7. Structure and function of electrical synapses

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2-7Quiz

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Unit 2-8. Neural signal transmission across chemical synapses

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2-8Quiz

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Week 3. Synaptic transmission: mechanisms

Unit 3-1.The nerve-muscle synapse end-plate potential

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3-1Quiz

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Unit 3-2.The time course of the end-plate potential

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3-2Quiz

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Unit 3-3.Current through single acetylcholine receptor-channels

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3-3Quiz

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Unit 3-4.Structure of acetylcholine receptor-channels

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3-4Quiz

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Unit 3-5.Synaptic transmission in the central nervous system

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3-5Quiz

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Unit 3-6.Excitatory synaptic transmission in central neurons

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3-6Quiz

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Unit 3-7.Inhibitory synaptic transmission in central neurons

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3-7Quiz

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Unit 3-8.Synaptic integration in the central nervous system

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3-8Quiz

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Week 4. Synaptic transmission: neurotransmitters

Unit 4-1.Transmitter release is triggered by depolarization and calcium influx

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4-1Quiz

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Unit 4-2.Synaptic vesicles and quantal release

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4-2Quiz

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Unit 4-3.The synaptic vesicle cycle

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4-3Quiz

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Unit 4-4. Modulation of transmitter release

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4-4Quiz

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Unit 4-5.Small-molecule transmitters: acetylcholine

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4-5Quiz

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Unit 4-6.Small-molecule transmitters: biogenic amines and amino acids

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4-6Quiz

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Unit 4-7.Scene stabilization during saccades

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4-7Quiz

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Unit 4-8.Diseases of synaptic transmission

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4-8Quiz

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Week 5. Synaptic transmission: plasticity

Unit 5-1.G protein-coupled receptors and second messengers

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5-1Quiz

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Unit 5-2. Modulation of synaptic transmission

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5-2Quiz

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Unit 5-3. Long-lasting effects of synaptic transmission

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5-3Quiz

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Unit 5-4. Short-term storage of implicit memory

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5-4Quiz

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Unit 5-5. Long-term storage of implicit memory

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5-5Quiz

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Unit 5-6. Working memory and long-term potentiation in the hippocampus

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5-6Quiz

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Unit 5-7. Hebbian learning rule and early/late phases of long-term potentiation

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5-7Quiz

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Unit 5-8. Spatial learning and long-term memory

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5-8Quiz

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Week 6. Development of neurons

Unit 6-1. Patterning of the neural tube

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6-1Quiz

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Unit 6-2.? Regionalization and functional subtypes of neurons

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6-2Quiz

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Unit 6-3.? Proliferation, differentiation, and neuronal cell fate

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6-3Quiz

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Unit 6-4.? Migration, differentiation, and the neurotransmitter phenotype of neurons

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6-4Quiz

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Unit 6-5. Survival and apoptosis of neurons

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6-5Quiz

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Unit 6-6. Establishment of neuronal polarity

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6-6Quiz

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Unit 6-7.? The growth cone of axon

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6-7Quiz

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Unit 6-8. Molecular cues of axon guidance

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6-8Quiz

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Week 7. Development of synapses

Unit 7-1.Growth of retinal ganglion axons

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Quiz7-1

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Unit 7-2.?Midline crossing of spinal neuron axons

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Quiz7-2

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Unit 7-3.Recognition of synaptic targets

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Quiz7-3

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Unit 7-4.?Synaptic differentiation in neuromuscular junction

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Quiz7-4

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Unit 7-5.Synaptic differentiation in central neurons and synapse elimination in neuromuscular junctions

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Quiz7-5

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Unit 7-6.Experience-dependent development of binocular circuits

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Quiz7-6

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Unit 7-7.?Reorganization of visual circuits in a critical period

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Quiz7-7

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Unit 7-8.?Activity-dependent refinement of auditory maps

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Quiz7-8

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Week 8. Degeneration and regeneration of neurons

Unit 8-1.Axon degeneration and regeneration

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Quiz8-1

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Unit 8-2.Regeneration of injured central neurons

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Quiz8-2

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Unit 8-3.Neurogenesis in the central nervous system

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Quiz8-3

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Unit 8-4.Regenerative therapies

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Quiz8-4

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Unit 8-5.Trinucleotide repeat diseases

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Quiz8-5

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Unit 8-6.Parkinson disease

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Quiz8-6

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Unit 8-7.The aging brain

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Quiz8-7

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Unit 8-8.Alzheimer disease

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Quiz8-8

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Course Descriptions

腦科學為21世紀最重要的研究領域，而神經科學即是腦科學的基礎。本課程將介紹神經細胞的基本構造與功能、神經訊號的產生與傳遞、神經細胞間的溝通與塑性、神經細胞的發育與改變、神經系統的退化與再生。藉由重要觀念的解說與實驗數據的分析，本課程期望所有修習的學生都能對神經細胞的特性有充分的瞭解，做為探索腦功能的重要基礎。

本課程提供線上測驗，但不提供線上成績單，僅提供成績顯示。

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指定用書

Eric R. Kandel, James H. Schwartz, Thomas M. Jessell, Steven A. Siegelbaum and A. J. Hudspeth, Principles of Neural Science, 5th Ed., 2012.

特別感謝書商麥格羅﹒希爾(McGraw-Hill)提供書籍圖片授權以俾進行影片製作，以下為此書籍之連結資訊。(點我開啟 )

參考資料

Dale Purves, George J. Augustine, David Fitzpatrick and William C. Hall, Neuroscience, 5th Ed., 2011.
Larry Squire, Darwin Berg, Floyd E. Bloom and Sascha du Lac, Fundamental Neuroscience, 4th Ed., 2012.
John G. Nicholls, A. Robert Martin, Paul A. Fuchs and David A. Brown, From Neuron to Brain, 5th Ed., 2011.

先修課程

具備生物學基本概念即可

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國立清華大學生命科學系教授

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聯絡方式： ccchiao@life.nthu.edu.tw

研究專長

視覺科學、神經行為學、視網膜生理學

學歷

馬里蘭大學生物科學系博士

經歷

國立清華大學教務長

國立清華大學系統神經科學研究所所長

國立清華大學教學發展中心主任

哈佛大學醫學院博士後研究員

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2024-自學課程-細胞神經科學(1-6月)

Course Descriptions

How students rated this courses

4.5

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What’s included

焦傳金

11,604

32

12,230